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Abstract #3054

Hyperpolarized 13C MR Spectroscopic Imaging in a Regression Study of a Switchable RAS-Oncogene Model of Liver Cancer

Minhua Zhu1, Asha Balakrishnan2, Simon HU3, Pedar E.Z. Larson3, Sarah J. Nelson3, John Kurhanewicz3, Andrei Goga3, Daniel B. Vigneron3

1radiology and biomedical imaging, ucsf, San Francisco, CA, United States; 2Dept. of Medicine, Division of Hematology/Oncology, University of California, San Francisco, CA; 3radiology and biomedical imaging, ucsf, San Francisco, CA, United States,

Hyperpolarized technology using dynamic nuclear polarization has been developed and used in detecting signals of 13C metabolites in vivo at very high SNR [1]. In this work, hyperpolarized 13C 3D-MRSI using a 3D compressed sensing sequence [2] was used to measure liver metabolism in mice which developed abnormal size of the liver after expression of the RAS oncogene was switched on in the liver. After the liver developed into an abnormal state at a relatively late stage, the regression of the later disease stages before and after turning off the oncogene were studied, and significant differences in hyperpolarized lactate and alanine levels were detected.