Meeting Banner
Abstract #3057

Quantification of Lactate Concentrations in Orthotopic Breast Tumors with Different Growth Rates

Sanjay Annarao1, Sunitha Thakur1, 2

1Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; 2Department of Radiology, Memorial Sloan-Kettering Cancer Centre, New York, NY, United States

We measured Lac with improved lipid and water suppression using 1331 binomial composite pulses using SS1-SelMQC sequence. Using this sequence Lac levels were quantified in orthotopic breast tumors with different growth rates. MCF-7 and BT-474 breast tumors were used to represent fast growing tumors compared with slow growing MDA-MB-231 and MDA-MB-435 tumors. The [Lac] was found to be higher in lower tumor volume, as tumor volume becomes more, [Lac] declined. The statistical analysis shows the relationship between tumor volume and Lac level in slice. In all these cell lines, the tumor volume is negatively correlated with [Lac].