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Abstract #3060

Arterial Spin Labeling-Based Longitudinal Monitoring of CBF and CVR Following Permanent Unilateral Ligation of the Common Carotid Artery

Tom Struys1, 2, Tom Dresselaers1, Sarah Caers1, Wouter Oosterlinck3, Ann Van Santvoort1, Ivo Lambrichts2, Uwe Himmelreich1

1Department of Medical Diagnostic Sciences, Katholieke Universiteit Leuven, Leuven, Belgium; 2Department of Functional Morphology, Universiteit Hasselt, Diepenbeek, Belgium; 3Cardiovascular Diseases, Katholieke Universiteit Leuven, Leuven, Belgium

This study reports on the longitudinal changes in CBF and CVR, assessed by ASL, in free breathing and ventilated animals which underwent a permanent unilateral ligation of the common carotid artery (CCA). Data indicate that a specific vascular response is elicited upon CCA ligation which suggests a temporal limitation in auto regulation of the vascular network and a spontaneous recovery over time. These findings provide a better understanding of the effect of a permanent CCA ligation and how it contributes to the interpretation of the dynamics observed in the penumbra CBF in the mouse transient MCAO model for stroke.