Meeting Banner
Abstract #3067

Imaging Seizure-Induced Inflammation Using an Antibody Targeted Iron Oxide Contrast Agent

Ben A. Duffy1, ManKin Choy2, Johannes Riegler1, Jack A. Wells1, Daniel C. Anthony3, Rod C. Scott4, Mark F. Lythgoe1

1Centre for Advanced Biomedical Imaging (CABI), Department of Medicine, University College London, London, United Kingdom; 2Department of Pediatrics, University of California Irvine, Irvine, CA, United Kingdom; 3Experimental Neuropathology Laboratory, Department of Pharmacology, University of Oxford, Oxford, United Kingdom; 4Institute of Child Health, University College London, London, United Kingdom

Neuroinflammation has been implicated in both seizure induced brain injury and the development of epilepsy. This study demonstrates that it is possible to image regional VCAM-1 expression in vivo following prolonged seizures in rats. This molecular imaging approach demonstrates a highly sensitive marker of acute neuroinflammation.