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Abstract #3071

The Role of Oxygen Molecule Dissolved in Rat Blood Based on BOLD MRI

Youngkyu Song1, 2, Song-I Chun1, Hengjun Kim1, DONG WAN LIM1, Young Ro Kim3, Jeong Kon Kim2, Gyunggoo Cho1

1Korea Basic Science Institute, Cheongwon, Chungbuk, Korea, Republic of; 2University of Ulsan College of Medicine, Seoul, Korea, Republic of; 3Massachusetts General Hospital, Lexington, MA, United States

To accurately interpret the meaning of BOLD signals, it is important to assess the effect of oxygen on SI changes observed during oxygen breathing. Such assessment is important particularly for explaining unusual signal intensity changes. In these regards, (a) for analyzing the contribution of oxygen to blood SI changes, we compared T1 and T2/T2* relaxation times between normoxic and hyperoxic blood samples; and (b) for exploring the effect of tissue oxygen on BOLD signal, we compared T1 relaxation time and SI changes according to TE between normoxic and hypoxic brain tissue.