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Abstract #3087

Multi Nutrient Enriched Diets Restore Cerebral Perfusion and Protect Against Neurodegeneration in a Mouse Model for Alzheimers Disease

MAGNA25Valerio Zerbi1, 2, Diane Jansen1, Maximilian Wiesmann1, Maartje Mutsaers1, Pieter J. Dederen1, Ilse Arnoldussen1, Andor Veltien2, Sjaak Van Asten2, Arend Hee

1Anatomy, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; 2Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

Increasing evidence supports the importance of lifestyle especially dietary intake, in sharing a protective action in Alzheimers disease (AD) and cardiovascular diseases. In this study, we therefore evaluated the effects of a long term dietary intake of multi-nutrient lipid diets on cerebral blood flow (CBF) and hippocampal metabolite levels in an AD mouse model (APP/PS1). Results showed that 12-month-old APP/PS1 mice have decreased CBF and that specific combinations of multicomponent enriched diets are able to restore cerebral perfusion into physiological values, with signs of decreased neurodegeneration, suggesting a potential efficacy of multi-nutrient lipid diets in slowing AD progression.