Shape of the DSC Residue Data Acute in Ischemic Stroke

Jeffry R. Alger¹, David S. Liebeskind¹, Noriko Salamon², Jeffrey L. Saver¹, Danny JJ Wang¹

We studied the shape of the residue data that are derived in DSC studies of patients having acute ischemic stroke. Our results indicate that DSC residue data can be modeled as a Gaussian shaped washout function having a half time of 5 8 sec over a wide range of CBF and CBV, including those typically found in ischemic core and penumbra. The absence of a strong relationship between CBF and residue half time indicates that nature achieves higher per unit mass flow rates by increasing the blood volume rather than by increasing the rate of flow through the microvessel system.