Jeffry R. Alger1, Danny JJ Wang1, Sunny Q. Hao1, Michael G. Ho1, Noriko Salamon2, Jeffrey L. Saver1, David S. Liebeskind1
1Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 2Radiological Sciences, Geffen School of Medicine at UCLA, Los Angeles, CA, United States
We sought to define the relationship between Tmax and absolute quantitative CBF in Dynamic Susceptibility Contrast studies of acute ischemic stroke. Doing so may provide insight into past successes and failures associated with using Tmax as a predictive parameter in addition to defining whether Tmax should continue to be used. Although Tmax is effective at detecting core ischemia, there does not appear to be a Tmax threshold that detects core ischemia with a high discriminatory power. Given that absolute CBF now be reliably obtained, thresholding of CBF images may provide a more reliable means of identifying core ischemic tissue volumes.
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