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Abstract #3112

Segmentation of a Novel Lesion Type from MTR Images for Multiple Sclerosis Clinical Trials

Robert A. Brown1, Sridar Narayanan1, Douglas L. Arnold1

1Montreal Neurological Institute, McGill University, Montreal, QC, Canada

Multiple sclerosis is characterized by white matter lesions which are apparent on T2-weighted MRI. Lesions that enhance on T1-weighted scans with gadolinium contrast agent have also been used extensively as a surrogate marker in trials of new treatments. However, neither of these lesion types is specific to myelin destruction or repair. We suggest a new type of lesion, segmented from MTR images that are specific to myelin, and demonstrate their utility for clinical trials in an example study of remyelination in multiple sclerosis.