Functional Connectivity Reveals Abnormal Affective, Executive and Sensorimotor Resting State Networks in Psychotropic Nave Patients with Pediatric Mania

Minjie Wu¹, Lisa H. Lu¹, ², Alessandra M. Passarotti¹, Ezra Wegbreit¹, Jacklynn Fitzgerald¹, Mani N. Pavuluri¹

An understanding of the neural operations impacted by pediatric bipolar disorder (PBD) is essential for the discovery of optimal treatment targets for this serious illness. The present study evaluates the resting state functional connectivity underlying structural and functional abnormalities reported in PBD using model-free independent component analysis approach. Three distinct resting state networks, comprising regions involved in affective, executive, or sensorimotor functions, exhibited significant differences in regional connectivity between PBD and healthy control (HC) groups.