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Abstract #3144

Altered Hippocampal Connectivity Network Associated with Impulsivity in Abstinent Heroin Addicts

Tianye Zhai1, 2, Chunming Xie, 12, Wenjun Li2, Zheng Yang1, Shi-Jiang Li2

1Center of Brain and Cognition, Beijing Institute of Basic Medical Science, Beijing, China; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

Neurobiological and neuroimaging studies have demonstrated that the hippocampus, as a major node of memory processing, is involved in drug addiction. However, little is known about the role of hippocampal network and its relation to drug-seeking behaviors such as impulsivity in addiction. In this study, we utilized resting-state functional connectivity fMRI (R-fMRI) to investigate the alteration of hippocampus functional connectivity (HFC) network and its relation to impulsivity in abstinent heroin dependent subjects (HD) and control non-drug users (CN).