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Abstract #3152

Structural Connectivity of the Default Mode Network in Adolescents with Autism Spectrum Disorders

Li-Ting Liu1, Shur-Fen Susan Gau1, 2, Ay-Woan Pan1, 2, Wen-Yih Isaac Tseng3, 4

1Department of Occupational Therapy, National Taiwan University, Taipei, Taiwan; 2Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; 3Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan

This study aimed to investigate the structural connectivity of DMN in adolescents with ASD and typically developing (TD) adolescents. The DSI image of 13 adolescents with ASD (aged 15.00.94) and 13 age-, sex-, and handedness-matched TD adolescent were acquired on a 3T MRI system and performed using a twice-refocused balanced EPI sequence. The predefined ROIs were processed by the LDDMM normalization and transformation procedure, we successfully tracked the 15 fiber bundles of DMN in adolescents with ASD and TD. However, our study provides weak evidence showing that structural connectivity within DMN might be altered in adolescents with ASD.