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Abstract #3177

Evaluation of Human Brain Metastases Using Molecular MRI Based on Endogenous Protein-Based Amide Proton Transfer (APT) Signals

MAGNA25Silun Wang1, Zhibo Wen2, Jing Gu1, Ge Zhang2, Xianlong Wang2, Fanheng Huang2, Peter C.M. van Zijl1, 3, Jinyuan Zhou1, 4

1Departments of Radiology, The Johns Hopkins University, Baltimore, MD, United States; 2Department of Radiology, Zhujiang Hospital,, Southern Medical University, Guangzhou, Guangdong, China; 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute , Baltimore, MD, United States; 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

We explored the imaging features of brain metastases using APT imaging of endogenous mobile proteins and peptides at 3 Tesla. Results showed that the metastasis tumor core had significantly higher APT signal intensities, compared to adjacent peritumoral edema and normal-appearing white matter. Metastases from small cell lung cancer had significantly lower APT signal intensities than those of lung adenocarcinoma and other adenocarcinomas. APT imaging provides additional diagnostic information to characterize brain metastases non-invasively.