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Abstract #3191

Utility of Multiple B-Value DWI Derived Metrics in Differentiation of High Grade from Low Grade Glioma

Bhaswati Roy1, Rishi Awasthi1, Prativa Sahoo2, Ram KS Rathore2, Rakesh Kumar Gupta1

1Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 2Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India

Sixteen (11 male and 5 female; mean age=41 yrs) untreated consecutive patients (11 high grades & 5 low grades on histopathology) with a postoperative diagnosis of either high or low grade glioma were imaged on 3T scanner, using multi b-value DWI (0 to 2000s/mm2) and DCE MRI. On Students independent t-test, none of the DWI derived ADC, fp, Dslow and Dfast showed any significant differences between high and low grade glioma whereas all the DCE derived metrics except ve were found to be significantly higher in high grade as compared to low grade glioma. We conclude that multi b-value DWI is not a reliable technique to differentiate between high and low grade glioma and DCE perfusion MRI is still the best available technique to differentiate as well as characterize the glial neoplasm.