Investigating the Relationship Between the Apparent Diffusion Coefficient and Extravascular Extracellular Volume Fraction in Patients with Vestibular Schwannomas Undergoing Bevacizumab Treatment

Ka-Loh Li¹, Sha Zhao², Amy Watkins¹, Xiaoping Zhu¹, Alan Jackson¹

Investigating the relationship between the apparent diffusion coefficient (ADC) and the extravascular extracellular volume (ve) from DCE-MRI will lead to better understanding the two parameters as imaging biomarkers for cancer treatment response. We compare the two parameters for patients with vestibular schwannomas over the course of bevacizumab treatment. A dual injection DCE-MRI technique was employed. Pre-treatment tumor median ADC and median ve values were well correlated. This relationship was lost after treatment. This study may provide useful information for ve and ADC as imaging biomarkers for evaluation of cancer treatment response in vestibular schwannomas over the course of bevacizumab treatment.