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Abstract #3214

Differential Effects of Fractionated and Single Radiation Dose on Diffusion Tensor Imaging in Mice Brain

Mamta Gupta1, Richa Trivedi1, Poonam Rana1, Ahmad Raza Khan1, Rajendra P. Tripathi1, Subash Khushu1

1Institute of Nuclear Medicine and Allied Sciences, Delhi, India

Longitudinal diffusion tensor imaging (DTI) study was performed at baseline, day 1, day 3, and day 5 after fractionated and single 8gy cranial irradiation of mice brain. A subsequent decrease in FA values were observed at both day3 and day5 in hippocampus in fractionated 8 gy irradiation group, whereas in single 8y irradiation in addition to hippocampus change in DTI measures were also observed in caudate-putamen and corpus callosum regions. Our results demonstrate radiation induced microstructural changes in brain parenchyma even in case of fractionated dose during acute phase even before conventional MRI.