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Abstract #3223

Hybrid Diffusion Imaging (HYDI) of Mild Traumatic Brain Injury (MTBI)

Yu-Chien Wu1, Thomas W. McAllister2

1Dartmouth Brain Imaging Center, Dartmouth College, Hanover, NH, United States; 2Psychiatry, Dartmouth Medical School, United States

HYDI was used to estimate diffusion measures in individuals with MTBI (one month and one year after injury), and age and gender matched healthy controls. Both PDF and DTI measures, including Po, MSD, FA, MD, Da, and Dr, were assessed in whole brain white matter, as well as the genu, splenium and body of the corpus callosum. Histograms of Po in genu and splenium of the corpus callosum showed the greatest separation between MTBI and control subjects. Histograms of FA and other diffusion measures showed little or no difference. Little change in PDF and DTI measures was observed over time.