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Abstract #3235

Assessment of Atlas Warping of Small Basal Ganglia on Colin27

Lara Bailey1, Yiming Xiao1, Mallar M. Chakravarty2, Abbas F. Sadikot3, D. Louis Collins1

1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; 2Kimel Family Translational Imaging-Genetics Laboratory, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada; 3Division of Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Canada

Localization of basal ganglia (BG) is necessary for deep brain stimulation, but is difficult to achieve with clinical MRI. A method for warping a histological atlas to a T1w target contrast was previously validated for larger BG structures, but not smaller structures only visible on T2w contrasts. Here, we manually labelled T2w Colin12 and compared it with the atlas segmentation. Overall, there was agreement between the labels, yet the accuracy is not sufficient to delineate borders of the subthalamic nucleus, substantia nigra, and red nucleus. In the future, we will improve registration of these structures by including a T2w contrast.