John Totenhagen1, Eriko Yoshimaru1, Robert Erickson2, Theodore Trouard1
1Biomedical Engineering, University of Arizona, Tucson, AZ, United States; 2Pediatrics, University of Arizona
High resolution in vivo MR images were collected in a mouse model of Niemann Pick type C (NPC) disease at 3 timepoints. Brain images were analyzed using volumetry and morphometry techniques to examine changes in brain anatomy as the neurodegenerative disease progressed.