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Abstract #3261

Assessment of Bone Marrow and Muscle Lipids in Acromegaly Using 1H Magnetic Resonance Spectroscopy

Hamed Mojahed1, Pamela Freda2, Christina Read3, Alex Dresner4, Truman R. Brown5, Fernando Arias-Mendoza3

1Department of Biomedical Engineering, Columbia University, New York, NY, United States; 2Department of Medicine, Columbia University; 3Department of Radiology, Columbia University; 4Philips Healthcare, Cleveland, OH, United States; 5Center for Advanced Imaging Research, Medical University of South Carolina, Charleston, SC, United States

Intra-myocellular lipid (IMCL) and diaphysis lipids of mixed sex acromegaly patients (including one outlier patient suspected of having a muscular degenerative disease) were studied with proton single voxel MR spectroscopy in a 1.5T Philips system. The IMCL normalized to total methyl and methylene lipid groups in diaphysis correlated with IMCL normalized to muscle water in all of the patients. However, excluding the outlier patient made the correlation more reliable. Hence studying muscle metabolites may be performed by normalizing to the bone marrow lipids but special caution must be exercised when studying patients with muscular degenerative diseases.