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Abstract #3263

Combined IDEAL and Diffusion Imaging to Characterize Limb-Girdle Muscular Dystrophy

R G. Hernandez-Salazar1, S Vargas-Caas2, S Hidalgo3, O Marrufo1, S Solis4, A Rodriguez5, R D. Delgado-Hernandez1

1Neuroradiology Dep, INNN-MVS, Mexico, DF, Mexico; 2Neurology Dep, INNN-MVS, Mexico, DF, Mexico; 3Phys Dep, UAM Iztapalapa, Mexico, DF, Mexico; 4Phys Dep, FC UNAM, Mexico, DF, Mexico; 5Electrical Engineering Dep, UAM Iztapalapa, Mexico, DF, Mexico

Limb-girdle muscular dystrophies (LGMD) are a group of autosomal dominantly or recessive inherited muscular dystrophies that also present with primary proximal (limb-girdle) muscle weakness, involving the shoulder and pelvic girdles, distinct phenotypic or clinical characteristics are recognized. MRI has great potential for non-invasive characterization of muscle properties in LGMDs utilizing techniques such as Dixon-based imaging for fat-water quantification and diffusion MRI for probing muscle microstructure. The aim of this study was to compare quantitative MRI measurements from Dixon-based imaging and DWI in the thigh muscles of adults with LGMDs and healthy volunteers.