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Abstract #3331

Chemical Exchange Saturation Transfer and T2 Mapping in Subjects with Intervertebral Disc Degeneration at 3 Tesla

Mina Kim1, Queenie Chan2, Marina-Portia Anthony1, Dino Samartzis3, Kenneth MC Cheung3, Pek-Lan Khong1

1Department of Diagnostic Radiology, University of Hong Kong, Hong Kong, SAR, China; 2Philips Healthcare, Hong Kong; 3Department of Orthopaedics and Traumatology, University of Hong Kong, Hong Kong, SAR, China

Chemical exchange saturation transfer (CEST) and T2 relaxation time were calculated in subjects with degenerative intervertebral discs (IVDs). Our results showed that CEST and T2 decreases with increasing grade of disc degeneration and that CEST values significantly correlated with T2. This study demonstrated a potential for the future use of MRI biomarkers in identifying early degenerative changes in the IVDs.