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Abstract #3366

Transmit Gain Calibration for Hyperpolarized 13C Patient Studies

Galen D. Reed1, Peder E.Z. Larson1, James Tropp2, Albert P. Chen3, Adam B. Kerr4, Mark van Criekinge1, Douglas A. C. Kelley5, John M. Pauly4, Kayvan R. Keshari1

1Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 2GE Healthcare, Fremont, CA, United States; 3GE Healthcare, Toronto, Ontario, Canada; 4Electrical Engineering, Stanford University, Stanford, CA, United States; 5GE Healthcare, San Francisco, CA, United States

With hyperpolarized 13C magnetic resonance imaging in the early stages of clinical translation, methods of characterizing transmitter inhomogeneity and calibration of transmit gain become increasingly important. This study presents double angle spectra acquired from a hyperpolarized 13C scan of a human prostate as well as a field mapping using the Bloch Siegert shift with ethylene glycol phantoms for the characterization of transmitter nonuniformity. This nonuniformity was incorporated into the patient study as a 2 dB attenuation adjustment, and the efficacy of this approach was validated in the in vivo patient exam.