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Abstract #3375

Tumour Progression with Parametric Maps of Endogenous CEST at 7T

Kim Desmond1, Firas Moosvi1, Greg J. Stanisz1, 2

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

Parametric maps of endogenous CEST Z-spectrum properties (amide, OH-, and mobile lipid peaks) were obtained in five mice with Lewis lung carcinoma xenografts at 7T. Maps were generated by decomposing the spectrum for each voxel into the sum of four Lorentzian functions of variable amplitude and width representing the major endogenous proton pools. The growth of the tumour was followed for five days, and an increase in mean peak amplitude was observed for each pool.