Kotaro Sekiya1, 2, Memi Watanabe1, Osamu Sakai1, Rohini N. Nadgir1, Adham A. Mottalib1, Mingxin Zheng3, Hernan Jara1
1Boston Medical Center, Boston University School of Medicine, Boston, MA, United States; 2Nihon University Graduate School of Dentistry at Matsudo, Chiba, Japan, Japan; 3Graduate Student of Biomedical Engineering Department, Boston University, Boston, MA, United States
Purpose: To develop a technique for mapping the qMRI T1/T2 ratio and to study the hierarchical order of T1/T2 ratio values of the normal human head. Methods: A variant of the mixed turbo spin echo pulse sequence which is multispectral in PD, T1, and T2 was used at 3T. Images were processed with qMRI algorithms to generate T1/T2 ratio maps and whole head histogram. Results: The resulting T1/T2 ratio maps exhibit dark CSF and bright muscles. The cerebral tissues appear in the hierarchy of signal intensities of a T2-weighted fluid attenuated with inversion recovery (T2W-FLAIR) image. Conclusion: A technique for mapping the T1/T2 relaxometric ratio has been developed.