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Abstract #3417

Mapping the T1/T2 Ratio of the Human Head with Multispectral QMRI at 3T

Kotaro Sekiya1, 2, Memi Watanabe1, Osamu Sakai1, Rohini N. Nadgir1, Adham A. Mottalib1, Mingxin Zheng3, Hernan Jara1

1Boston Medical Center, Boston University School of Medicine, Boston, MA, United States; 2Nihon University Graduate School of Dentistry at Matsudo, Chiba, Japan, Japan; 3Graduate Student of Biomedical Engineering Department, Boston University, Boston, MA, United States

Purpose: To develop a technique for mapping the qMRI T1/T2 ratio and to study the hierarchical order of T1/T2 ratio values of the normal human head. Methods: A variant of the mixed turbo spin echo pulse sequence which is multispectral in PD, T1, and T2 was used at 3T. Images were processed with qMRI algorithms to generate T1/T2 ratio maps and whole head histogram. Results: The resulting T1/T2 ratio maps exhibit dark CSF and bright muscles. The cerebral tissues appear in the hierarchy of signal intensities of a T2-weighted fluid attenuated with inversion recovery (T2W-FLAIR) image. Conclusion: A technique for mapping the T1/T2 relaxometric ratio has been developed.