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Abstract #3506

Sampling Duration in DCE-MRI: in vivo Comparison Using Data Acquired Within a Clinical Phase I Study

Martin Buechert1, Henrik Gille2, Jan Kuhlmann3, Klaus Mross4

1MRDAC Magnetic Resonance Development and Application Center, University Medical Center Freiburg, Freiburg, Germany; 2Pieris AG, Freising, Germany; 3University Medical Center, Freiburg, Germany; 4Klinik fr Tumorbiologie, Freiburg, Germany

For assessing treatment response DCE-MRI is a valuable tool. Parameters calculated using pharmacokinetic modeling may depend on the sampling duration which equals the number of sampled data points for equally distributed sampling. This was previously investigated by computer simulations but there is limited verification of these findings using real in vivo patient data. This dependency on sampling duration of the Ktrans, Ve and the fit accuracy were investigated using patient data with a long sampling duration in comparison to an artificial shortened sub set of these data. Results were in agreement with the published simulations.