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Abstract #3512

Accounting for Pre-Capillary Signal in Arterial Spin Labelling Perfusion Measurements

Michael A. Chappell1, 2, Thomas W. Okell2, Bradley J. MacIntosh3, Peter Jezzard2, Stephen J. Payne1

1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom; 2FMRIB Centre, University of Oxford, Oxford, United Kingdom; 3Department of Medical Biophysics, University of Toronto, Toronto, Canada

There a number of sources of signal in Arterial Spin Labelling perfusion measurements. The major components that have been addressed to date are label undergoing exchange in the capillaries from which blood flow measurements can be obtained and that remaining in large arteries. However, it has been proposed that signal in impermeable small arterial vessels before the capillary space may also need to be accounted for. In this work the effects of pre-capillary signal on flow and blood volume estimation using multi-inversion time data and a model-based analysis strategy are examined.