Thomas W. Okell1, Michael A. Chappell2, Peter Jezzard1
1FMRIB Centre, Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, Oxfordshire, United Kingdom
Quantification of cerebral blood flow (CBF) may be confounded in brain regions fed by multiple arteries with different transit delays, as may be the case in patients with significant collateral flow. Vessel-encoded pseudocontinuous arterial spin labeling (VEPCASL) generates artery specific perfusion maps, allowing the fitting of a kinetic model to each arterial component separately. Here we compare CBF quantification and signal-to-noise ratio (SNR) using VEPCASL to conventional PCASL in healthy volunteers. Despite reduced SNR, the CBF estimates from VEPCASL were comparable to those from PCASL. Therefore VEPCASL may improve CBF quantification in cases of mixed blood supply.