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Abstract #3532

Comparison of Permeability Estimates Derived from DCE-MRI and DCE-CT Data in a Rodent Stroke Model

Andrea Kassner1, 2, Meah Gao2, Jackie Leung1, Madison McGregor2, Neil Sokol2, David Mikulis2, 3

1Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Medical Imaging, University of Toronto, Toronto, Ontario, Canada; 3Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada

Loss of blood-brain barrier (BBB) integrity in acute ischemic stroke is a precursor to hemorrhagic transformation. Dynamic contrast enhanced (DCE) CT and MR imaging can quantify the integrity of the BBB when used with a suitable pharmacokinetic model. We compared DCE-CT and DCE-MRI permeability ratios in a rodent stroke model using the same pharmacokinetic model and determined a statistically significant correlation between the two modalities. The results of this study open up the possibility for multi-modal DCE studies.