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Abstract #3547

Potential Misinterpretation of Diffusion Tensor Imaging Data Due to Head Motion

A. Alhamud1, M Dylan Tisdall2, 3, Khader M. Hasan4, Andr J.W. van der Kouwe2, 3, Ernesta M. Meintjes1

1University of Cape Town, Cape Town, WC, South Africa; 2Athinoula A. Martinos Center for Biomedical Imaging; 3Department of Radiology, Harvard Medical School; 4University of Texas Health Science Center, Houston, United States

Previously, we introduced volumetric navigators (3D-EPI) to perform prospective motion correction in diffusion tensor imaging (DTI) that allows real-time tracking of head pose. The navigated diffusion sequence has been further modified to reacquire motion corrupted diffusion volumes during which the motion exceeded a pre-defined threshold. The purpose of this work is to highlight the effect of subject head motion and the effects of retrospective and prospective motion correction with the reacquisition on the diffusion data, in particular, the fractional anisotropy (FA) of the whole brain-white matter (WM).