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Abstract #3556

Effect of Registration on Fractional Anisotropy Values

Kurt Hermann Bockhorst1, Priya Goel1, Ponnada A. Narayana1

1DII, University of Texas, Houston, TX, United States

Registration is commonly used during the post processing of medical imaging data. However, the effect of registration on the quantification of imaging metrics as DTI has not been reported recently. The submitted abstract documents a significant decrease of FA values (up to 20%) in the white matter (splenium and genu) of rat brains after registration. We studied this phenomenon with four different types of registration: AIR, FSL, DTI-TK (tensor based) and ANTS. All of these methods caused a significant decrease in FA.