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Abstract #3558

Impact of Noise Correction on Diffusion Kurtosis Estimation

Elodie Andr1, Evelyne Balteau2, Christophe Phillips2, Ezequiel Farrher3, Ivan Maximov3, Farida Grinberg3, N. Jon Shah3, 4

1Cyclotron Research Centre, University of Lige , Lige, Belgium; 2Cyclotron Research Centre, University of Lige, Lige, Belgium; 3Institute of Neuroscience and Medicine - 4, Forschungszentrum Jlich GmbH, Jlich, Germany; 4JARA - Faculty of Medicine, RWTH Aachen University, Aachen, Germany

Low SNR is a critical issue in diffusion kurtosis imaging because of the use of high b-values (up to 3000 s mm-2). We tested different noise correction methods prior to kurtosis fitting and show that noise correction is a necessary step in kurtosis processing, providing higher tissue contrast and better parameter estimates.