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Abstract #3584

HARDI-Based Methods for Fiber Orientation Estimation

SUMMA25Ben Jeurissen1, Alexander Leemans2, Jacques-Donald Tournier3, 4, Jan Sijbers1

1Vision Lab, University of Antwerp, Antwerp, Belgium; 2Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 3Brain Research Institute, Florey Neuroscience Institutes (Austin), Melbourne, Victoria, Australia; 4Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

In voxels containing multiple fiber orientations, diffusion tensor imaging (DTI) has been shown to provide misleading white matter orientation integrity information. Several methods have been proposed to extract fiber orientation information from the diffusion-weighted signal, many of them relying on the high angular resolution diffusion imaging (HARDI) protocol. The purpose of this presentation is to review the most widely-used methods for extracting fiber orientation information from single-shell HARDI data. From this overview, the need for multi-fiber reconstruction algorithms should be clear as well as the advantages and limitations of the different multi-fiber reconstruction methods.