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Abstract #3603

Diffusion Kurtosis Imaging Analysis of Microstructural Differences Between Patients with Alzheimer's Disease and Mild Cognitive Impairment

Nanjie Gong1, Chun Sing Wong1, Chun Chung Chan2, Lam Ming Leung2, Yiu Ching Chu3, Queenie Chan4

1Diagnostic Radiology, The University of Hong Kong, Hong Kong, China; 2United Christian Hospital, Hong Kong; 3Kwong Wah Hospital, Hong Kong; 4Philips Healthcare, Hong Kong

To investigate the sensitivity of the measurements from DKI for differentiating between patients with MCI and patients with AD and detecting microstructural changes in both white matter and grey matter, we used region of interest (ROI) analysis focusing on the ROIs that have been previous investigated using DTI model in other studies. We hypothesize that with more precise model and additional information provided by DKI matrix, we could not only better differentiate between MCI and AD, but also better characterize the microtructural alternations.