Abstract #3606

Water Diffusional Kurtosis Imaging (DKI) Analysis of Ischemic Stroke Model in Juvenile Rats

Renaud NICOLAS¹, Grard RAFFARD², Stphane SANCHEZ³, Eric PETERSON³, Florent AUBRY⁴, Isabelle BERRY⁵, Pierre CELSIS⁵, Bassem HIBA³

¹Imagerie crbrale et handicaps neurologiques; UMR 825, INSERM, F-31059 Toulouse, , France; ²Centre de Rsonance Magntique des Systmes Biologiques,UMR 5536, CNRS,, F-33076 Bordeaux, France; ³Centre de Rsonance Magntique des Systmes Biologiques,UMR 5536,, CNRS,, F-33076 Bordeaux, France; ⁴Imagerie crbrale et handicaps neurologiques; UMR 825,, INSERM, F-31059 Toulouse,, France; ⁵Imagerie crbrale et handicaps neurologiques; UMR 825, INSERM, F-31059 Toulouse,, France

DWI images of 7 juvenile rats following MCAO were acquired with b-factors up to 2500 s/mm and with three diffusion times (10,30,50 ms)and analysed with the Statistical Model of Diffusion Imaging that provide a way to estimate Diffusional Kurtosis of ischemic brain regions. A statistically significant change for Dapp (40 % reduction) and Kapp (55 % rise) were observed in ischemic versus healthy cortex. No significant effects of diffusion times were observed in this preliminary study.