Abstract #3630

Regional Values of the Diffusional Kurtosis in the Healthy Brain

Danielle Van Westen¹,², Markus Nilsson³, Nils Karlsson², Mikael Johansson⁴, Freddy Sthlberg,²³, Pia C. Sundgren,¹², Jimmy Ltt¹

¹Center for Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden; ²Diagnostic Radiology, Lund University, Lund, Sweden; ³Department of Medical Radiation Physics, Lund University, Lund, Sweden; ⁴Institute for Psychology, Lund University, Lund, Sweden

Regional values of the diffusional kurtosis, previously reported in a very limited number of structures, were determined in thirty-six healthy individuals in a large number of anatomically defined areas. Mean kurtosis varied from 1.38 in the splenium of the corpus callosum to 0.66 in the caudate head. Estimates in previously studied areas were well in line with those. Linear age-dependency for mean kurtosis was found in some regions, but no quadratic relationship with age, which may be due to the limited number of individuals studied.