Abstract #3636

Diffusion Tensor Tractography Studies Correlate with Neuropsychometric Tests in Patients of Vitamin B12 Deficiency with Normal Appearing Brain on Conventional MRI

Pradeep K. Gupta¹, R. K. Garg², R. Verma², V. K. Paliwal³, M. K. Singh², Y. Rai¹, R. S. Rathore⁴, R. K. Gupta¹

¹Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India; ²Department of Neurology, Chattrapati Sahuji Maharaj Medical University, Lucknow, UP, India; ³Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India; ⁴Department of Mathematics & Statistics, Indian Institute of Technology, Kanpur, UP, India

Vitamin B-12 deficiency may leads to microstructural changes in brain white matter. The purpose of this study was to determine the change in DTI metrics in brain white matter and to find out its association with cognitive function among patients with vitamin B-12 deficiency. In this study, we included 8 patients with vitamin B-12 deficiency and 9 healthy controls. ATR and PTR fibers showed significant reduction in FA values with abnormal cognitive function in these patients. These changes in ATR and PTR in patients with vitamin B12 deficiency with normal appearing conventional MRI suggest these findings may be used as image biomarkers of B12 deficiency in future.