Meeting Banner
Abstract #3648

Brain Diffusion and Perfusion Alternations in Chronic Obstructive Pulmonary Disease (COPD)

Geon-Ho Jahng1, Chang-Woo Ryu1, Min-Ji Kim1, Hyug-Gi Kim1, Sun Mi Kim1, Dal Mo Yang1, Dong Wook Sung2, Woo-Suk Choi2

1Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University, Seoul, Korea, Republic of; 2Radiology, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea, Republic of

A cognitive deficit is a common problem in patients with chronic obstructive pulmonary disease (COPD). To prospectively evaluate if MRI can demonstrate the microstructural volume loss, the diffusion and/or cerebral blood flow (CBF) changes in subjects with COPD compared with cognitively normal (CN) elderly subjects, 6 subjects with severe COPD, 13 with moderate COPD, and 12 CN subjects underwent isotropic volumetric T1-weighted imaging and diffusion tensor imaging (DTI), and arterial spin labeling perfusion imaging. Voxel-based statistical analyses among groups were performed on brain volumes, fractional anisotropy (FA) and trace, and CBF by ANOVA tests.