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Abstract #3673

Altered Default Mode Network Functional Connectivity in Amyotrophic Lateral Sclerosis

Pan Lin1, Ming Zhang2, Chenwang Jin2, Cuiping Mao2, Chen Niu2, Xin Liu1, Zhigang Min2, Qiaoting Jin3, Jingxia Dang3

1Key Laboratory of Biomedical Information Engineering of Education Ministry,Xi'an Jiaotong University, Xi'an, Shannxi, China; 2Department of Medical Imaging, the First Affiliated Hospital of Medical College,Xian Jiaotong University, Xi'an, Shaanxi, China; 3Department of Neurology, the First Affiliated Hospital of Xian Jiaotong University, Xi'an, Shaanxi, China

Characterization of the default mode network as a complex network of functionally interacting dynamic systems has received great interest for clinical application. ALS is a progresssive disease that is associated with motor disorder. Little is know about how ALS affects the defualt mode network. The aim of this study is to assess the complex network of DMN while in the resting state, which can provide greated insight into how DMN functional networks are affected by ALS.