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Abstract #3677

Defrosting Parkinsons Disease: Exploring the Neural Correlates of Freezing of Gait.

James M. Shine1, Philip Ward2, Elie Matar1, Sharon Naismith1, Simon Lewis1

1Brain and Mind Research Institute, The University of Sydney, Sydney, NSW, Australia; 2School of Psychiatry, The University of New South Wales

Freezing of gait (FOG) is a devastating symptom of advanced Parkinsons disease in which patients suddenly feel as though their feet have become stuck to the ground. Despite a well-characterised clinical phenotype, the condition remains poorly understood. To remedy this, we have combined fMRI with a novel virtual reality walking paradigm, allowing the safe recreation of freezing of gait episodes and the subsequent exploration of the neural correlates of these episodes. In a cohort of 16 patients, we found robust patterns of activation that were consistent with the predictions of a recently-proposed model.