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Abstract #3707

VEGF Enhance the Permeability of the Blood-Brain Barrier

Shize Jiang1, Rui Xia1, Lei Wang1, Fabao Gao1

1Department of Radiology, Molecular Imaging Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China

The blood-brain barrier (BBB) is one of the most important interfaces that keep the homeostasis of brain. However, it also prevents drugs from entering in morbid state. VEGF is an important growth factor that promotes neovascularization. We think it might be helpful to increase the permeability of the BBB. To test this hypothesis, we used KM mice with the venous injection of Hu-VEGF165 and detect the permeability of the BBB both in MRI and histological methods. We find that VEGF can increase the permeability of the BBB and may be a new direction for the CNS drugs delivery.