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Abstract #3720

Structural Connectivity Analysis of the Pedunculopontine Nucleus Region in Parkinsonian Syndroms

Clarisse Longo dos Santos1, 2, Oliver Riff1, Claire Ewenczyk3, 4, Jerme Yelnik3, 5, Cecile Gaudebout3, 4, Eric Bardinet2, 6, Linda Marrakc

1Neurospin, CEA/I2BM, Gif-sur-Yvette, France; 2CR-ICM / CENIR, Paris, France; 3CR-ICM / AP-HP, Groupe Hospitalier Piti-Salptrire, Facult de Mdecine, Paris; 4Centre dInvestigation Clinique, Fdration des Maladies du Systme Nerveux, France; 5INSERM; 6CNRS-UMR7225, France

We have combined structural and diffusion magnetic resonance imaging to investigate the connectivity of the pedunculopontine nucleus (PPN) region in Parkinson's disease and Progressive supranuclear palsy patients. A total of 87 participants were recruited, including 45 patients PD, 12 patients PSP and 30 age-matched controls. Images were acquired using a 3T (Trio Siemens; T1; T2; diffusion 60 directions b-value 1500s/mm) and a 7T (Trio Siemens; T2* 0.6x0.6x0.6mm3).