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Abstract #3731

Characterization of Pediatric Bipolar Disorder with Quantitative HARDI Tractography Metrics

Ryan Payne Cabeen1, Daniel Dickstein2, David H. Laidlaw1

1Computer Science, Brown University, Providence, RI, United States; 2Psychiatry & Human Behavior, Brown University, Providence, RI, United States

We computed and compared quantitative diffusion tractography metrics in three children with bipolar disorder (BD) and three typically-developing controls (TDC) without psychiatric illness. An automated process was used to choose tracks connecting the amygdala and accumbens, a track of interest (TOI) chosen a priori from previous findings in voxel-based morphometry (VBM) and resting state functional connectivity (RSFC) analysis. We found decreases in mean FA and sum length-weighted FA in left hemisphere tracks of the BD group. No differences were found in right hemisphere metrics or subcortical volumes.