Pablo Garcia-Polo Garcia1, Juan Antonio Hernndez-Tamames2, Roberto Garca-lvarez3, Eva Alfayate4, Juan lvarez-Linera5
1Neuroimaging Lab., Centre for Biomedical Imaging, Pozuelo de Alarcn, Madrid, Spain; 2Universidad Rey Juan Carlos, Mstoles, Madrid, Spain; 3Research and Collaborations Department, GE Healthcare, Buc, France; 4Cien Foundation - Centre for Alzheimer's Disease Queen Sofia Foundation, Madrid, Spain; 5Hospital Ruber Internacional, Madrid, Spain
Alzheimer's disease (AD) is a type of dementia that exhibits decreased perfusion-metabolism and GM loss in the brain. This work examines the correlation between both rCBF-ASL and FDG-PET in a group of 24 subjects. In addition, ASL was utilized in a second group of 99 subjects (Control, MCI and AD) to assess hypoperfusion in AD. Significant correlation between rCBF and FDG-PET was found. Hypoperfusion patterns were seen in posterior cingulate and posterior lobes in AD. This work demonstrates both: a high correlation between ASL and FDG-PET, and the capability of ASL to become a promising technique to monitor the AD.
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