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Abstract #3755

Distinct Longitudinal Cortical Change in Frontotemporal Lobar Degeneration and Alzheimer's Disease

Brian B. Avants1, Corey McMillan2, Philip A. Cook1, James C. Gee3, Murray Grossman2

1University of Pennsylvania, Philadelphia, PA, United States; 2Neurology, University of Pennsylvania, Philadelphia, PA, United States; 3Radiology, University of Pennsylvania, Philadelphia, PA, United States


We employ quantitative longitudinal neuroimaging to contrast cortical atrophy rates between controls and patients with Alzheimer's disease (AD) or frontotemporal degeneration (FTD) defined on the basis of autopsy-confirmed cerebrospinal fluid (CSF) values of tau:Abeta1-42 ratio. We demonstrate that unbiased quantification of specific cortical regions improves detection power over whole brain analysis in both AD and FTD.