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Abstract #3761

Postmortem MRI Reveals Alterations in T2 Associated with Histopathologically Verified Alzheimers Disease and Other Pathology in the Elderly Human Brain

Robert Dawe1, Julie Schneider1, David Bennett1, Konstantinos Arfanakis, 12

1Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States; 2Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States

Using postmortem MRI, we mapped T2 in 228 fixed cerebral hemispheres. After spatial registration, we performed voxelwise analysis of covariance to identify T2 alterations associated with histopathologically confirmed Alzheimers disease and other neuropathology among the elderly. T2 prolongation was observed in association with Alzheimers disease in the white matter of the temporal, frontal, and parietal lobes. T2 prolongation in association with gross infarcts was observed throughout the majority of white matter and was most intense in the frontal lobe. This study demonstrates the utility of postmortem T2 mapping and provides candidates for MRI-based biomarkers of disease.