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Abstract #3848

Respiration-Resolved Ventricular Function Evaluation Using a 5D Cardiac MRI Technique

Holden H. Wu1, 2, Dwight G. Nishimura2, Michael V. McConnell1, 2, Bob S. Hu2, 3

1Cardiovascular Medicine, Stanford University, Stanford, CA, United States; 2Electrical Engineering, Stanford University, Stanford, CA, United States; 3Palo Alto Medical Foundation, Palo Alto, CA, United States

Conventional MRI methods for evaluating cardiac function seek to suspend or counteract respiratory motion to avoid artifacts. However, in many disease states, including pericardial constriction and heart failure with preserved ejection fraction (HFpEF), it is precisely the changes in cardiac function associated with changes in respiration-induced intra-thoracic pressure that can reflect the pathophysiology. In this work, we employ a respiration-resolved 5D cardiac MRI technique in combination with controllable modulation of the intra-thoracic pressure to provide a more comprehensive assessment of ventricular function.