Abstract #3962

Ventilation Quantification Using Volumetric Interpolated Breath-Hold Examination (VIBE): Preliminary Findings

Yulin V. Chang¹, James D. Quirk¹, Francesca Pennati², Ramsey Hachem³, Andrea Aliverti², Jason C. Woods¹

¹Radiology, Washington University, Saint Louis, MO, United States; ²Biomedical Engineering, Politecnico di Milano, Milan, Italy; ³Internal Medicine, Washington University, St. Louis, MO, United States

We present our preliminary results on quantification of pulmonary ventilation using proton magnetic resonance imaging (MRI) of the lung at different volumes. Images were acquired at 1.5 T field using volumetric interpolated breath-hold examination (VIBE). The image-intensity differences were computed after image registration as measures of tissue-density changes, which are compared with hyperpolarized ³He images. Our results indicate proton MRI is promising at detecting significant ventilation defects in the lung.