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Abstract #3994

Comparison of Pulmonary Function Testing with Distribution of Alveolar Oxygen Tension and Apparent Diffusion Coefficient in Asymptomatic Smokers Using Hyperpolarized 3He MRI

Hooman Hamedani1, Kiarash Emami1, Stephen J. Kadlecek1, Yi Xin1, Puttisarn Mongkolwisetwara1, Biao Han1, Harrison McAdams2, Masaru Ishii3, G. Wilson Miller4

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Biological Basis of Behavior Program, University of Pennsylvania, Philadelphia, PA, United States; 3Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States; 4Radiology, University of Virginia, Charlottesville, VA, United States; 5Medicine, University of Pennsylvania, Philadelphia, PA, United States

Ten healthy non-smokers and twenty asymptomatic smokers participated in a hyperpolarized 3He ADC and pAO2 MRI imaging. 12 slices with thickness of 13mm were acquired for each subject during 12-second breath-hold with a reasonable spatial resolution. Before each MRI session, a pulmonary function test was performed. Imaged ADC and pAO2 distributions of whole-lung were regressed on PFT results and ANNOVA test was performed to study the power of discriminatory of MRI metrics in distinguishing the smokers from nonsmokers.