Abstract #3994

Comparison of Pulmonary Function Testing with Distribution of Alveolar Oxygen Tension and Apparent Diffusion Coefficient in Asymptomatic Smokers Using Hyperpolarized 3He MRI

Hooman Hamedani¹, Kiarash Emami¹, Stephen J. Kadlecek¹, Yi Xin¹, Puttisarn Mongkolwisetwara¹, Biao Han¹, Harrison McAdams², Masaru Ishii³, G. Wilson Miller⁴

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Biological Basis of Behavior Program, University of Pennsylvania, Philadelphia, PA, United States; ³Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States; ⁴Radiology, University of Virginia, Charlottesville, VA, United States; ⁵Medicine, University of Pennsylvania, Philadelphia, PA, United States

Ten healthy non-smokers and twenty asymptomatic smokers participated in a hyperpolarized 3He ADC and pAO2 MRI imaging. 12 slices with thickness of 13mm were acquired for each subject during 12-second breath-hold with a reasonable spatial resolution. Before each MRI session, a pulmonary function test was performed. Imaged ADC and pAO2 distributions of whole-lung were regressed on PFT results and ANNOVA test was performed to study the power of discriminatory of MRI metrics in distinguishing the smokers from nonsmokers.