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Abstract #3996

Elevated Short-Time-Scale Hyperpolarized Helium-3 Diffusion in Secondhand Smokers

Chengbo Wang1, John P. Mugler, III1, 2, Eduard E. de Lange1, Talissa A. Altes1

1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States

Short-time-scale(STS) and long-time-scale(LTS) helium-3 diffusion were measured in 21 controls, 28 secondhand-smokers and 19 smokers. The STS and LTS ADC values of smokers were significantly elevated compared to controls and secondhand-smokers (P < 0.001 both). One-Way ANOVA analysis indicated that the mean STS ADC values from secondhand-smokers was significantly elevated compared with that of controls (increase for 10.2%, P=0.007) while not for the LTS ADC (increase 13.2%, P=0.238).