Abstract #3996

Elevated Short-Time-Scale Hyperpolarized Helium-3 Diffusion in Secondhand Smokers

Chengbo Wang¹, John P. Mugler, III¹,², Eduard E. de Lange¹, Talissa A. Altes¹

¹Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States; ²Biomedical Engineering, University of Virginia, Charlottesville, VA, United States

Short-time-scale(STS) and long-time-scale(LTS) helium-3 diffusion were measured in 21 controls, 28 secondhand-smokers and 19 smokers. The STS and LTS ADC values of smokers were significantly elevated compared to controls and secondhand-smokers (P < 0.001 both). One-Way ANOVA analysis indicated that the mean STS ADC values from secondhand-smokers was significantly elevated compared with that of controls (increase for 10.2%, P=0.007) while not for the LTS ADC (increase 13.2%, P=0.238).